BALTIMORE -- Kevin Youkilis wasted no time getting back into a groove at the plate in his first game off the disabled list.
Sidelined since April 29 with a strained lower back, Youkilis marked his return by hitting a towering drive over the center-field fence.
Unfortunately for the Boston Red Sox, that fourth-inning shot was the extent of their offense in a 4-1 loss to the Baltimore Orioles on Tuesday night.
Brian Matusz and three relievers combined on a two-hitter, and the Orioles got two-run homers from Steve Tolleson and Wilson Betemit in improving to 4-1 against Boston this season.
Red Sox starter Felix Doubront (4-2) gave up two runs and four hits in six innings and had a career-high nine strikeouts.
But Matusz was even better, yielding only two hits and a walk in 6 1/3 innings. He also had nine strikeouts, tying a career high.
"Felix Doubront had his good stuff," Red Sox manager Bobby Valentine said. "He was battling the whole way. He just picked a night when the opposing pitcher had good stuff and shut us down."
Doubront could only shrug his shoulders after a performance that usually results in a victory.
"He was good," Doubront said of Matusz. "I was talking to one of our guys. His stuff was working today. We got a pretty good duel, but he won the game."
The Red Sox were seeking to climb over .500 for the first time this season. Instead, Boston reclaimed sole possession of last place in the AL East.
"Both pitchers did a good job," Boston's Adrian Gonzalez said. "We just came out on the wrong end of it."
Matusz (4-4) was just too good.
The left-hander was 1-9 with a 10.69 ERA in 2011 and started 0-3 this season. Since then, however, he's won three straight starts and four of his last five.
"He didn't miss much," Boston catcher Jarrod Saltalamacchia said. "Kept the ball down. He did a pretty great job."
The lone glaring flaw in Matusz's effort was a fastball that Youkilis sent flying over the center-field wall. It was his third homer of the season, the first since April 26.
"That's as good a swing as I've seen Youk have," Valentine said. "Center field power. That was a good sight."
After Matusz left to standing ovation in the seventh, Darren O'Day struck out the final two batters in the inning. Pedro Strop worked a hitless eighth and Jim Johnson got three straight outs to complete the two-hitter and earn his 16th save in as many tries.
The difference was Tolleson, who came to the plate in the second inning with one home run in 62 career at-bats. With a runner on first, Tolleson sent a drive over the center-field wall.
"When I hit it, I said if that doesn't go out then I'm probably not going to hit one out," Tolleson said.
It was the first homer allowed by Doubront in five starts.
Betemit connected off former Oriole Matt Albers in the eighth.