TYRINGHAM — An estate on Jerusalem Road has been sold for $3.55 million — the third residential property sale in the Berkshires this year to top $3 million.

That’s something that has happened only twice in the past 13 years, according to the Berkshire County Board of Realtors: There were four such sales in 2007 and five in 2017.

A Cambridge entrepreneur has purchased Morningside Tyringham, which also has been known as Fernside, at 132, 137 and 140 Jerusalem Road from Fernside Properties LLC. The Fernside entity was formed by a New Jersey couple who purchased the estate in 2004, according to documents filed at the Middle Berkshire Registry of Deeds.

The owner is a partner in Global Oncology, a company whose mission is to bring the best cancer care to underserved patients around the world, according to its website. He also is a managing partner in GV, a firm that invests in enterprises in the life sciences, and consumer and future technology.

The 131-acre Tyringham property, which includes three residences, including an early 19th-century manor house built by a family that belonged to the Tyringham Shakers, originally had been listed at $4.03 million, according to Realtor.com.

When the property was purchased in September 2004 for $3.9 million, it was believed to be the largest residential property sale in the Berkshires up to that time. Seven residential property sales in the Berkshires over $3.9 million have been reported since then, topped by Elm Court in Stockbridge, which sold for $9.8 million in 2012.

It is the second-highest residential property sale in the Berkshires this year, behind only Underledge, an estate on Cliffwood Street in Lenox, that went for $3.6 million in May, according to the Berkshire County Board of Realtors. And a house on Interlaken Road in Stockbridge sold for $3.5 million in September, according to the board of realtors.

The $3.55 million price tag also places the sale just below the top 10 highest residential property sales in the Berkshires list compiled by The Berkshire Eagle. Underledge is 10th on that list.

Morningside Tyringham consists of two parcels at three addresses on Jerusalem Road, according to the deed. A parcel on the south side of Jerusalem Road contains 44 acres, while the lot on the northerly side of the roadway has 87 acres. The property is bordered by the Appalachian Trail on the south and east.

According to the listing, the estate includes a 16-room circa-1800 manor house, a three-bedroom house with a pool, a pool house, a swimming pond and gardens; and a 1,200-square-foot two-bedroom residence on 4.8 acres known as The Cottage.

C. Harry and Janet H. Knowles, of Moorestown, N.J., had purchased the property in 2004 from Barbara Crosby, according to Eagle files.

The couple founded and directed a publicly traded technology company, and a nonprofit science and teaching foundation.

J. Player Crosby, Barbara Crosby’s late husband, died in 2003, when the single-engine plane he was flying crashed after takeoff from a landing strip near the Jersualem Road property. The crash was attributed to a heart attack.