PITTSFIELD — Three men are facing felony drug charges after being arrested Friday with 500 bags of heroin and a loaded handgun in a vehicle headed into Pittsfield.

Devron Howard, 36, of Adams, and Isaac Howard, 42, and Kendall Hill, 33, both of Pittsfield, were stopped by police, who were acting on a tip about a heroin resupply run, according to a police report. Devron Howard and Hill also have Springfield addresses.

The Berkshire County Law Enforcement Task Force was informed that the three men would travel to Springfield on Friday to pick up more heroin to sell, the report said. Police tracked the vehicle the men were in as it traveled from Pittsfield to Lee and onto the Massachusetts Turnpike, then picked it up in Lee again on the return trip several hours later.

After stopping the vehicle, police seized 500 bags of heroin, with a street value of about $3,000, as well as the handgun and a digital scale, the report said. Devron Howard fainted outside of the car during the arrest.

A woman who had been driving the vehicle, which was a rental, was released at the scene, police said.

During booking, police also seized $431 from Isaac Howard’s pocket. They wrote in the report that the small amount of cash the men had on hand “further corroborates” the source’s information about the resupply.

All three men pleaded not guilty to possession of heroin with intent to distribute; possession of a loaded firearm without a license; improper storage of a firearm; possession of a firearm in the commission of a felony; possession of a firearm with prior drug or violent crime convictions; and conspiracy to violate the drug laws of the commonwealth.

Devron Howard and Isaac Howard were arraigned on Monday and ordered held without bail pending a dangerousness hearing on Wednesday. Hill, also arraigned, waived the hearing and is being held on dangerousness ahead of a pretrial hearing scheduled for Dec. 22.

Berkshire District Attorney Andrea Harrington said in a statement that the arrests are part of her office’s strategy to help people with substance use disorders while “prosecuting those who distribute illicit narcotics in our community.”

“The evidence law enforcement collected during these arrests suggests the individuals intended to distribute dangerous drugs in our county,” she said.

The investigation included members of the Berkshire County Sheriff’s Office, the Pittsfield Police Department, the Massachusetts State Police and the Berkshire County Special Response Team.

Friday’s arrests came just days after police busted four men suspected of belonging to an illegal drug ring based in Springfield. Police seized more than 13,000 bags of heroin in those arrests.

Francesca Paris can be reached at fparis@berkshireeagle.com and 510-207-2535.

Francesca Paris covers North Adams for The Berkshire Eagle. A California native and Williams College alumna, she has worked at NPR in Washington, D.C. and WBUR in Boston, as a news reporter, producer and editor. Find her on Twitter at @fparises.